Endocrine Abstracts

There is compelling evidence that certain families of endothelial cell-specific tyrosine kinases and their ligands (e.g. VEGFR/VEGF, Tie2/Ang) are essential for embryonic development and for angiogenesis in a wide variety of physiological and pathological circumstances. There is also evidence for a tissue-specific and tumor-specific regulation of endothelial cell growth and phenotype.We recently identified EG-VEGF, an endothelial cell mitogen with a unique selectivity, ess...

Background: β-thalassemia is associated with increased iron overload in endocrine tissues, including parathyroid glands. The occurrence of unbalanced calcium (Ca)-phosphorous (P) metabolism, such as chronic HPT, is higher in these patients compared to the general population. However, data about prevalence and presentation of HPT in this setting are scanty.Aim: To explore the biochemical characteristics of Ca-P metabolism, particularly the prevalence...

Background: Iron overload disorders (IOD) are associated with a higher occurrence of unbalanced calcium (Ca)-phosphorous (P) metabolism, including hypoparathyroidism (HPT). However, data about prevalence and presentation of HPT in this setting are scanty. A Ca/P ratio <2.32 has been proposed to detect HPT in the general population.Aim: To characterize Ca-P homeostasis, particularly the prevalence of HPT, in a cohort of adult patients with IOD compare...

Introduction: β-thalassemia (bT) is associated to several endocrine abnormalities mainly due to iron overload. With the increase in bT-patients life expectancy, due to progresses in iron chelation therapy, more patients enter into adulthood than in the past and the prevalence of endocrine diseases is being reconsidered. The aim of the study is to investigate the prevalence of primary hypoparathyroidism (pHPT) in adult bT-patients and to characterize the relative clinical ...

Introduction: Thyroid function is commonly impaired in β-thalassemic patients with an estimated prevalence of hypothyroidism of 9–11%. According to literature, iron overload is the main cause of tissue damage involving both thyroid and pituitary gland, thus leading to primary or secondary hypothyroidism respectively. However, thyroid morphology has been rarely investigated in adults. The aim of this study is to evaluate thyroid volume (TV) and thyroid morphology in &...

Injected depot formulations of somatostatin peptide analogs are routinely used to treat acromegaly and neuroendocrine tumors (NETs). Paltusotine (CRN00808), a small molecule nonpeptide selective somatostatin receptor 2 (sst2) agonist, is being evaluated for efficacy and safety in patients with acromegaly. The current Phase 1 study (NCT04246749) was conducted in two Parts: In Part A, the absorption, metabolism, excretion, and mass balance of a single oral dose of 20 mg [14C]-pa...

Objectives: Image-guided thermal-ablation (LTA; RFA) are well established therapy options in selected BTN. PMWT is a mini-invasive technique recently applied in thyroid disease; aim of this work is investigate its effectiveness as treatment in BTN.Methods: From May 2021, 45 patients (30 F, 15 M, Aged 37-90, Mean 55,8) with BTN symptomatic/in growing, refusing/non eligible to surgery were enrolled. Inclusion criteria: nodule diameter ≥ 2 cm, mainly ...

Introduction: Recent studies report the presence of KLK3 in women serum, KLK3 is excreted by Skene glands, it is involved in the production of cervical-vaginal fluid (CVF). Activation of KLK3 is pH depending, it has been hypothesized to have antimicrobial, immuno-regulator activity and vaginal and cervical epithelial desquamation. We intend to verify if KLK3 is present in female serum, in which menstrual cycle phases KLK3 ...

Introduction: Recent studies report the presence of KLK3 in women serum, KLK3 is excreted by Skene glands, it is involved in the production of cervical-vaginal fluid (CVF). Activation of KLK3 is pH depending, it has been hypothesized to have antimicrobial, immuno-regulator activity and vaginal and cervical epithelial desquamation. We intend to verify if KLK3 is present in female serum, in which menstrual cycle phases KLK3 ...

Paltusotine is an investigational oral, once-daily, non-peptide, SST2 agonist in development for the treatment of acromegaly and neuroendocrine tumors. Interim analysis results from subjects with acromegaly treated with paltusotine for up to 2 years in ACROBAT Advance (NCT04261712), an ongoing, open-label extension study are reported here. Prior to Advance, subjects previously completed one of two Phase 2 parent studies, Evolve (NCT03792555, with normal IGF-1 using injected lo...